Library of risk of bias tools

AMSTAR-2

Study design(s) targeted by the tool Systematic reviewssystematic-review
Additional details on designs Systematic reviews of interventions
Tool area Health
Link to the tool Get the AMSTAR-2 tool (PDF)

Details

Website https://amstar.ca/index.php
Primary publication Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ 2017;358
DOI 10.1136%2Fbmj.j4008
Guidance document Get the AMSTAR-2 guidance (PDF)
Training

None known – please contact us if you are aware of any training that should be listed here.

Language English
Translations

None known – please contact us if you are aware of any translations that should be listed here.

Record last updated 02/02/2024

Related tools and Publications

Previous versions

AMSTAR

Updated versions

None

Related tools

None

Evaluations

Gates A, Gates M, Duarte G, Cary M, Becker M, Prediger B, Vandermeer B, Fernandes RM, Pieper D, Hartling L. Evaluation of the reliability, usability, and applicability of AMSTAR, AMSTAR 2, and ROBIS: protocol for a descriptive analytic study. Systematic Reviews. 2018 Dec;7(1):1-7.

Lorenz RC, Matthias K, Pieper D, Wegewitz U, Morche J, Nocon M, Rissling O, Schirm J, Jacobs A. A psychometric study found AMSTAR 2 to be a valid and moderately reliable appraisal tool. Journal of clinical epidemiology. 2019 Oct 1;114:133-40.

Pieper D, Puljak L, González-Lorenzo M, Minozzi S. Minor differences were found between AMSTAR 2 and ROBIS in the assessment of systematic reviews including both randomized and nonrandomized studies. Journal of clinical epidemiology. 2019 Apr 1;108:26-33.

Leclercq V, Beaudart C, Tirelli E, Bruyère O. Psychometric measurements of AMSTAR 2 in a sample of meta-analyses indexed in PsycINFO. Journal of clinical epidemiology. 2020 Mar 1;119:144-5.

Swierz MJ, Storman D, Zajac J, Koperny M, Weglarz P, Staskiewicz W, Gorecka M, Skuza A, Wach A, Kaluzinska K, Bochenek-Cibor J. Similarities, reliability and gaps in assessing the quality of conduct of systematic reviews using AMSTAR-2 and ROBIS: systematic survey of nutrition reviews. BMC Medical Research Methodology. 2021 Dec;21:1-0.

Lorenz RC, Matthias K, Pieper D, Wegewitz U, Morche J, Nocon M, Rissling O, Schirm J, Freitag S, Jacobs A. AMSTAR 2 overall confidence rating: lacking discriminating capacity or requirement of high methodological quality?. Journal of Clinical Epidemiology. 2020 Mar 1;119:142-4.

Other publications

None known – please contact us if you are aware of any publications that should be listed here.

Key Criteria

Focuses on risk of bias, or makes a distinction between items that assess risk of bias and other aspects of study quality No
Offers a method to reach either a domain specific or overall assessment of risk of bias No
Tool development involving a range of stakeholders from different disciplines (e.g. methodologists, statisticians, clinicians) Yes
Avoids recommending use of summary numerical quality scores Yes