Library of risk of bias tools

CRIME-Q

Study design(s) targeted by the tool Animal studiesanimal-studies
Additional details on designs All aspects of animal models
Tool area Animal studies
Link to the tool Access the paper reporting the CRIME-Q tool

Details

Website
Primary publication Andersen, M.S., Kofoed, M.S., Paludan-Müller, A.S. et al. CRIME-Q - a unifying tool for critical appraisal of methodological (technical) quality, quality of reporting and risk of bias in animal research. BMC Med Res Methodol 24, 306 (2024)
DOI https://doi.org/10.1186/s12874-024-02413-0
Guidance document
Training

None known – please contact us if you are aware of any training that should be listed here.

Language English
Translations

None known – please contact us if you are aware of any translations that should be listed here.

Record last updated 03/06/2026

Related tools and Publications

Previous versions

None

Updated versions

None

Related tools

None

Evaluations

Paper reporting the tool article includes interrater reliability on 114 articles

Other publications

None known – please contact us if you are aware of any publications that should be listed here.

Key Criteria

Focuses on risk of bias, or makes a distinction between items that assess risk of bias and other aspects of study quality No
Offers a method to reach either a domain specific or overall assessment of risk of bias No
Tool developed for use across topic areas (i.e. not developed for specific clinical area such as physiotherapy or dentistry) Yes
Avoids recommending use of summary numerical quality scores Yes